The Incredible Shrinking Man. The shrinking man would have an advantage against the spider:
As for the contest with the spider, the battle is indeed biased, but not the way the movie would have you believe. Certainly the spider has a wicked set of poison fangs and some advantage because it wears its skeleton on the outside, where it can function as armor. But our hero, because of his increased metabolic rate, will be bouncing around like a mouse on amphetamines. He wouldn’t struggle to lift the sewing needle–he’d wield it like a rapier because his relative strength has increased about 70 fold.
This doesn’t account for the terror of facing a gigantic spider.